Charlotte is a senior medical student at the University of Southampton and an established member of the Soton Brain Hub team. She loves working with the Apple Pencil to create digital learning resources and wow - is she good at it! She also loves using emojis😘😍😭👌.

On this page we are sharing her clinically focused flashcards that help explain neuroanatomy and head & neck anatomy in an applied form to support medical students to integrate their knowledge. These images and their associated notes can also be found on our instagram page too.

Hydrocephalus is an excessive accumulation of cerebrospinal fluid (CSF) in the brain 🧠. It causes the ventricular system to enlarge, which typically causes increased intracranial pressure. If it is not treated, it can lead to permanent brain damage.

Symptoms of hydrocephalus can include headache 🤯 , vomiting 🤮, blurred vision 👀, poor

 balance, urinary incontinence, seizures, and a rapid increase in head size in babies (since the fontanelles of the skull have not yet fused) 👽

Hydrocephalus can be congenital or acquired. Congenital hydrocephalus can be caused by spina bifida or maternal infections in pregnancy (mumps and rubella).

The pathophysiology of hydrocephalus can be categorised as:

1️⃣ Increased CSF production (e.g. choroid plexus papilloma)

2️⃣ Decreased CSF absorption (e.g. meningitis, subarachnoid haemorrhage, normal pressure hydrocephalus)

3️⃣ CSF obstruction (e.g. congenital aqueduct stenosis, tectal plate glioma, colloid cyst)

It is treated with shunt surgery or endoscopic third ventriculostomy (ETV)

There are a number of dopaminergic pathways in the brain 🧠

The following 4️⃣ pathways are clinically relevant to to the action and side effects of antipsychotics, for the treatment of Schizophrenia. These are D2 antagonists that act by reducing dopamine levels.

1️⃣ MESOLIMBIC PATHWAY 🔵
Transmits dopamine from the midbrain (VTA) to the ventral striatum. It includes the nucleus accumbens (which is associated with motivations, emotions and rewards). This is thought to be responsible for the positive symptoms of Schizophrenia, which are reduced with antipsychotic use. 


2️⃣ MESOCORTICAL PATHWAY 🟢
Transmits dopamine from the midbrain (VTA) to the prefrontal cortex. Hypofunction of this pathway is thought to be responsible for the negative symptoms in Schizophrenia.

3️⃣ NIGROSTRIATAL PATHWAY 🟡
Transmits 80% of the brains dopamine from the pars compacta of the substantia nigra to the caudate nucleus and putamen. Antipsychotics that reduce dopamine can induce extrapyramidal side effects (similar to the pathophysiology of Parkinson’s disease).

4️⃣ TUBEROINFUNDIBULAR PATHWAY 🔴
Transmits dopamine from the hypothalamus to the pituitary gland. Dopamine in this pathway acts to inhibit prolactin. Blockade of D2 receptors by antipsychotics causes hyperprolactinaemia, and can result in breast enlargement, galactorrhoea, reduced libido and erectile dysfunction.

Migraine a common type of primary headache🤦
It typically causes a severe, unilateral, throbbing headache, and is associated with nausea, vomiting, photophobia and phonophobia. It can last up to 72 hours.

Migraines can occur with and without aura (neurological symptoms). Auras are most commonly visual disturbances and can include blind spots, flashes and scotoma 💥✨. However, auras may also consist of paraesthesia, weakness and vertigo.

Common triggers for a migraine are tiredness, stress, alcohol, menstruation, the combined oral contraceptive pill,
hunger, dehydration, cheese 🧀, chocolate🍫, red wine🍷 citrus 🍋 and bright lights. It 3 times more common in women.

Focal seizures are seizures arising from a focal area within one hemisphere of the brain. They can progress to generalised seizures 🧠

Frontal lobe focal seizures may show signs including head or leg movement, abnormal posturing and Jacksonian march (a phenomenon in which the seizure starts at the distal part of a limb and progresses towards the ipsilateral face, like a “march”) 🦵

Parietal lobe focal seizures often consist of sensory symptoms like tingling, pain and temperature changes 🌡

Occipital lobe focal seizures involve visual phenomena such as colours, flashes of light and scotoma 👁🌈💥

Temporal lobe seizures are the most common of the focal seizures. Its signs can be remembered by “HEAD”’
- Hallucinations (which can be auditory, olfactory or gustatory)👂👅
- Emotions or an epigastric rising sensation ⬆️
- Automatisms (non-purposeful repetitive behaviours e.g. lip smacking) 👄
- Déjà vu 

 

Alzheimer’s disease is the most common form of dementia. It has a slower and more insidious onset than many other types of dementia. 


Macroscopically, the brain in Alzheimer’s disease exhibits generalised cerebral cortex atrophy (especially of the medial temporal lobe), widening of sulci, enlarged ventricles (a compensatory mechanism), and atrophy of the hippocampus 🧠.

The hippocampus is critical for the formation of new memories, so it is unsurprising that patients with Alzheimer’s often have deficits in short term memory.

Other early features include word finding difficulties 🗣, decision making difficulties🤷, apathy and mood changes🙁.

Later, patients may exhibit behavioural and psychological symptoms (like agitation and aggression), delusions, sleep disorders, physical frailty, incontinence, weight loss and communication difficulties.

Addison’s disease is a rare disorder of the adrenal glands. It is also known as primary adrenal insufficiency. It can be life threatening.

Damage to the adrenal glands (usually autoimmune) results in insufficient production of steroid hormones (including cortisol and aldosterone).


To try and maintain homeostasis, the hypothalamus stimulates the pituitary gland to release more ACTH to stimulate the adrenal glands to produce more steroid hormones.

This also has the effect of increasing melanocyte-stimulating hormone, which results in the characteristic bronze skin pigmentation in Addison’s disease🌞.

Other signs and symptoms include weight loss⚖️, low blood pressure, hypoglycaemia, GI disturbance (nausea🤢, vomiting, abdominal pain, constipation), muscle weakness, increased thirst, fatigue and low mood😔. Treatment involves lifelong replacement of the steroid hormones💊

Glioblastoma Multiforme is the most common type of primarybrain tumour, with around 4,500 new cases in the UK per year. It is the most malignant type of astrocytoma (grade 4), which are brain tumours that develop from astrocytes.

Radiologically it appears as a heterogenous ring enhancing lesion within the brain with irregular margins, surrounded by an area of oedema. It typically has a central area of necrosis.

Symptoms vary and depend on the size and location of the tumour. They may include headache (due to raised intracranial pressure)🤯, nausea and vomiting🤢, seizures and focal neurological symptoms (e.g. weakness, numbness, visual disturbance, speech problems).


Management depends on the size and location of the tumour, and the general health of the patient. Complete excision of the tumour is preferable but often difficult 😷🔪. Adjuvant chemotherapy with temozolomide 💉and radiotherapy may also be used. Other options include biopsy and palliative care.

Pituitary adenomas are slow growing, benign tumours that arise in the anterior pituitary gland. They can be hormone secreting or non-hormone secreting.

Depending on the hormone secreted, pituitary adenomas can cause different symptoms:

1️⃣ Prolactin secretion ➡️ low libido, amenorrhoea (in women), impotence (in men), galactorrhoea, infertility
2️⃣ Growth hormone secretion ➡️ acromegaly
3️⃣ ACTH secretion ➡️ Cushing’s disease

Additionally, large pituitary adenomas (macroadenomas) may cause the classic bitemporal hemianopia (a favourite of exam questions!) due to suprasellar extension and compression of the optic chiasm.                                                                                                                                                                                    Rarely when a macroadenoma outgrows its blood supply, spontaneous haemorrhage and infarction can occur within it (pituitary apoplexy). This is a medical emergency! 


The primary treatment for most patients with secreting pituitary adenomas is surgical resection. This is typically an endoscopic endonasal trans-sphenoidal decompression.

The surgeon passes the endoscope through the nose and accesses the pituitary gland via the sphenoid sinus. This technique is popular as it is minimally invasive and avoids the need for a craniotomy.

An acoustic neuroma (also known as a vestibular schwannoma) is benign tumour of the Schwann cells around the vestibulocochlear nerve (CN8).
They account for 5% of intracranial tumours and 90% of cerebellopontine angle tumours.

Bilateral vestibular schwannomas are seen in neurofibromatosis type 2️⃣.
Signs and symptoms of an acoustic neuroma depend on its size and the cranial nerves affected. They can be predicted when you know the anatomy.

Features may include:

☑️Vestibulocochlear nerve (CN8): vertigoo🌪, unilateral sensorineural hearing loss👂, unilateral tinnitus

☑️Trigeminal nerve (CN5): absent corneal reflex👁, unilateral facial numbness, weakness of the muscles of mastication😬

☑️Facial nerve (CN7): ipsilateral facial palsy🥴, hyperacusis (noise sensitivity), impaired lacrimation😢, loss of taste of the anterior 2/3 of the tongue👅

A large acoustic neuroma could also affect the glossopharyngeal (CN9) and vagus (CN10) nerves, have mass effect on the cerebellum (ataxia, ipsilateral cerebellar syndrome) and the brainstem, and cause hydrocephalus.
Management may be observation, radiotherapy or surgical resection.

Creutzfeldt-Jakob disease (CJD) is a very rare and fatal degenerative brain disorder. CJD is a type of prion disease, which is caused by an infectious protein known as a prion.

A prion protein is a normal structural component of the nervous system 🧠. However, it can become misfolded. This alters its tertiary structure but its amino acid sequence remains the same. A misfolded prion protein can catalyse the conversion of other normal prion proteins (PrPc) into abnormal ones (PrPsc) in a chain reaction 📈. These abnormal prion proteins accumulate in the brain causing irreversible damage.                                                                                                                                                                                                     

This causes vacuolation in the grey matter of the brain and results in a spongy appearance histologically 🧽. It is known as spongiform encephalopathy. 

CJD can be sporadic❓ (most common), acquired (variant CJD), familial 🧬 (due to a mutation in the PRNP gene) or iatrogenic (e.g. from a contaminated corneal transplant or blood transfusion🩸). Variant CJD is caused by consuminginfected material, such as beef 🥩 from a cow with bovine spongiform encephalopathy - also known as ‘Mad Cow Disease’🐄.

Symptoms are often rapidly progressive and can include ataxia, slurred speech, involuntary movements (myoclonus), muscle weakness, visual disturbance, behavioural change and dementia.The definitive diagnosis is via brain biopsy 🔬(usually post mortem).There is no available treatment and most patients die within 1 year of symptom onset.